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Information
NexGard COMBO for Cats – Flea, Tick, Worm & Heartworm Protection
NexGard COMBO for Cats is an all-in-one topical solution designed to provide comprehensive monthly protection against both internal and external parasites. Formulated with esafoxolaner, eprinomectin, and praziquantel, it helps protect your cat from fleas and ticks, prevents heartworm disease, and treats and controls common intestinal worms. This easy-to-apply spot-on treatment eliminates the need for oral dosing, making parasite protection simpler and less stressful. It starts killing fleas within 24 hours and controls ticks within 48–72 hours, delivering reliable, month-long protection. Suitable for cats and kittens from 8 weeks of age and weighing at least 1.8 lbs, it supports consistent, broad-spectrum care.
Coverage
- Kills adult fleas and helps prevent infestations
- Controls ticks (including black-legged and lone star ticks)
- Helps prevent heartworm disease
- Treats and controls roundworms
- Treats and controls hookworms
- Treats and controls tapeworms
- Provides full-spectrum internal and external parasite protection
How It Works
NexGard COMBO combines three active ingredients to target multiple parasites.
- Esafoxolaner disrupts the nervous system of fleas and ticks, leading to rapid elimination
- Eprinomectin helps prevent heartworm disease and treats internal parasites
- Praziquantel eliminates tapeworms effectively
The formula spreads across the skin after application, providing protection for up to one month.
Directions
- Keep the product in its original packaging until ready to use.
- Cut the blister along the dotted line and remove the applicator.
- Hold the applicator upright and remove the cap.
- Part the hair at the base of the neck between the shoulder blades.
- Apply the entire contents directly onto the skin in one spot.
- Ensure the application site is an area your cat cannot lick.
- If multiple applications are required based on weight, apply in the same manner.
- Wash hands thoroughly after use.
- Apply once monthly for continuous protection.
Dosage:
| Cat Weight | Volume | Esafoxolaner | Eprinomectin | Praziquantel | Pack Color |
| 1.8–5.5 lbs | 0.3 mL | 3.6 mg | 1.2 mg | 24.9 mg | Purple |
| 5.6–16.5 lbs | 0.9 mL | 10.8 mg | 3.6 mg | 74.7 mg | Yellow |
Key Benefits
- All-in-one monthly parasite protection
- Covers fleas, ticks, heartworm, and intestinal worms
- Easy topical application with no oral dosing required
- Starts killing fleas within 24 hours
- Controls ticks within 48–72 hours
- Provides one-month continuous protection
- Suitable for kittens from 8 weeks of age
- Available in weight-specific dosing options
- Supports complete parasite management in a single treatment
Safety
- For topical use in cats only
- Do not use in kittens under 8 weeks or weighing less than 1.8 lbs
- Avoid contact with the application site until dry
- May cause mild eye irritation if contact occurs
- Keep out of reach of children
- Do not allow ingestion of the product
- Consult your veterinarian before use in cats with health concerns
More Info
Ingredients
Esafoxolaner, Eprinomectin and Praziquantel
Suitability
- Cats and kittens aged 8 weeks and older
- Cats weighing at least 1.8 lbs
- Suitable for indoor and outdoor cats
Available Options
- 3-dose pack
- 6-dose pack
- 12-dose pack
Available in weight-based options:
- 1.8–5.5 lbs (Purple, 0.3 mL)
- 5.6–16.5 lbs (Yellow, 0.9 mL)
Helpful Tips
- Apply monthly for consistent parasite protection
- Choose the correct dose based on your cat’s weight
- Avoid touching the application site until fully dry
- Maintain regular parasite prevention year-round
- Store in a cool, dry place away from light
Reviews
Multi-Benefit
Covers multiple parasites effectively.
Must try
It works good. Really a must try.
Great combo product
NexGard Combo works well for my cat and is easy to apply.


