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NexGard Combo vs. Revolution plus – A Detailed Study

  Jul 17, 2025

NexGard Combo vs. Revolution plus – A Detailed Study

Cats are cute, little furballs that bring a lot of happiness to our lives. However, parenting a feline baby is not always hunky-dory. It takes a lot of hard work to ensure their good health and keep them protected from internal and external parasite infestations. Thankfully, there's a wide range of treatments available on the market that are equipped to deal with major types of parasites. However, the plethora of options can often overwhelm and confuse pet parents. That's why we are here to help!

In this blog, we will compare two preferred parasitic treatments for cats – NexGard Combo and Revolution Plus. We will also take a look at the key features, parasitic coverage, similarities, and differences to help you choose a suitable treatment for your kitty. Read on to find out more:

NexGard Combo & Revolution Plus – An Overview

Here's a quick overview of NexGard Combo and Revolution Plus.

NexGard Combo for Cats

Nexgard Combo for Cats

Formulated for kittens and cats from 8 weeks of age that weigh at least 1.8 lbs, NexGard Combo is a topical monthly formula, indicated for the prevention of heartworm disease caused by Dirofilaria immitis. It also treats and controls roundworms, hookworms, and tapeworms. The treatment kills adult fleas and treats and prevents flea infestations. Additionally, it treats and controls tick infestations caused by black-legged ticks and lone star ticks.

Shop Nexgard Combo for Cats at Lowest Prices

Revolution Plus for Cats

Revolution Plus for Cats

Suitable for kittens and cats from 8 weeks of age that weigh at least 2.8 lbs, Revolution Plus is a monthly topical treatment that prevents heartworm disease caused by Dirofilaria immitis. It also treats and controls roundworms and hookworms and is indicated for the treatment and control of ear mite infestations.

The topical formula also kills adult fleas and treats and prevents flea infestations, as well as flea tapeworm infections. The treatment also treats and controls tick infestations caused by lone star ticks, Gulf Coast ticks, American dog ticks, and black-legged ticks.

Shop Revolution Plus for Cats at Lowest Prices

Similarities & Differences

Let's discuss the similarities and differences between NexGard Combo and Revolution Plus.

The Similarities:

  • NexGard Combo and Revolution Plus are formulated in topical treatments, and they should be administered once every month.
  • Both treatments protect cats against heartworm disease caused by Dirofilaria immitis.
  • NexGard Combo and Revolution Plus are effective against roundworms and hookworms.
  • Both products kill adult fleas and treat and prevent flea infestations.
  • NexGard Combo and Revolution Plus treat and control tick infestation caused by black-legged ticks and lone star ticks.
  • The minimum age requirements of both treatments is 8 weeks.
  • Both products are formulated for monthly administration.
  • The safe use of both NexGard Combo and Revolution Plus has not been evaluated in breeding, pregnant, and lactating cats.

The Differences

  • Revolution Plus treats and controls tick infestations caused by Gulf Coast ticks and American dog ticks. NexGard Combo does not protect against these tick species.
  • While Revolution Plus treats and controls ear mite infestations, NexGard Combo doesn't.
  • While the active ingredients of NexGard Combo are Esafoxolaner, Eprinomectin, and

Praziquantel, Revolution Plus is composed of Selamectin and Sarolaner as its active ingredients.

  • NexGard Combo is suitable for cats and kittens weighing at least 1.8 lbs. Revolution Plus can be used in felines weighing from 2.8 lbs.

A Detailed Comparison

Here's a detailed comparison between NexGard Combo and Revolution Plus.

Nexgard Combo vs Revolution Plus for Cats Comparison Chart 2025

Wrapping Up

NexGard Combo and Revolution Plus are vet-recommended topical treatments for cats. They are effective against multiple species of internal and external parasites. However, the products differ in composition, parasitic coverage, and weight criteria.

If you want coverage against heartworm disease, fleas, tick species like black-legged ticks and lone star ticks, roundworms, hookworms, and tapeworms, you can administer either of the treatments. However, if you’re looking for coverage against tick species like Gulf Coast ticks and American dog ticks, you should go for NexGard Combo. And if you want coverage against ear mites, you should opt for Revolution Plus. You will just have to make sure your cat meets the minimum age and weight criteria mentioned in the treatments' product labels.

Both NexGard Combo and Revolution Plus are available on OurPetWarehouse at discounted prices. Visit our online store today to enjoy unbeatable offers on your preferred products.


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