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Simparica Trio: A One-Chew Solution for Multiple Parasitic Problems

  Aug 16, 2023

Simparica Trio: A One-Chew Solution for Multiple Parasitic Problems

Picture this: your dog is happily roaming in your home, on the lawn, without any discomfort or illness. But then your pooch's happiness is invaded by nettlesome parasites that can cause health problems and suffering for your pet.

This thought is horrible, right? Now, what if we say that you can prevent this from happening and safeguard your pet from fleas, ticks, and nasty worms?

Introducing Simparica Trio, a one-stop solution to treat, control, and prevent parasitic diseases in your pet! This multi-spectrum treatment is all you need to save your pet from troublesome parasites.

Simparica Trio: All-in-One Treatment for Parasites

Simparica Trio is a one-of-a-kind chewable treatment for your dog that provides protection against fleas, ticks, and worms. These liver-flavored chews are so delicious that your pet can’t resist it.

Whether you are looking for flea and tick treatment or heartworm disease prevention, Simparica Trio is a scientifically proven solution. It contains a triple-action formula that

  • Kills fleas and ticks
  • Prevents heartworm disease
  • Treats and controls roundworms and hookworms

This Zoetis-manufactured chewable is suitable for dogs and puppies and comes in different packs and sizes. So whether you have a pup or a fully grown dog, you are sure to find a relevant Simparica Trio chewable!

The All-Rounder Simparica Trio Formula

Simparica Trio has a more advanced formula than its predecessor, Simparica, which included Sarolaner. The new, improved formula comprises Sarolaner, Moxidectin, and Pyrantel Pamoate, which together provide all-around protection for your pet.

The Simparica Trio provides protection against the following internal and external parasites:


  • Kills fleas.
  • Prevent reinfestation.


  • Kills five species of ticks.
  1. Gulf Coast Ticks
  2. Deer Ticks (aka black-legged ticks)
  3. American Dog Ticks
  4. Lone Star Ticks
  5. Brown Dog Ticks

Intestinal Worms:

  • Kills roundworms (Immature adults, adult Toxocara canis, and adult Toxascaris leonina).
  • Kills hookworms (L4, immature adults, adult Ancylostoma caninum, and adult Uncinaria stenocephala).


How Does the Simparica Trio Work?

Simparica Trio contains three active ingredients, Sarolaner, Moxidectin, and Pyrantel Pamoate, responsible for the parasiticidal activity of the chew.

All three ingredients act on parasites and protect your pet.

Sarolaner, an isoxazoline derivative, is an acaricide (poisonous to ticks and mites) and insecticide (for fleas and other insects). When ingested by insects, Sarolaner inhibits neurotransmission by blocking gamma-aminobutyric acid (GABA) receptors and glutamate receptors, thus inhibiting neuromuscular function. This leads to uncontrolled neuromuscular activity, resulting in death.

Moxidectin, a macrocyclic lactone derivative, is an endectocide (kills nematodes and arthopods). It induces paralysis and death in parasites by interfering with chloride channel-mediated neurotransmission.

Pyrantel pamoate, a tetrahydropyrimidine derivative, is a nematocide (kills nematodes, or worms). It acts as a depolarizing neuromuscular blocking agent and disrupts the neuromuscular function of the parasite. This leads to paralysis and the death of the parasite.

Why is the Simparica Trio the Best Solution for Parasitic Problems?

Dogs are prone to various parasitic infestations, including ticks, fleas, heartworms, and whatnot! While there are plenty of treatments available on the market, getting a different treatment for each ailment is not practical.

Simparica Trio offers monthly protection against all aforementioned parasites, adding convenience to your life. Furthermore, the liver-flavored chews are highly palatable, so you don't have to run after or manhandle your pet when administering this treatment.

Some key benefits of using Simparica Trio over other parasiticides on the market include:

  • One chew provides monthly protection against both endo- and ectoparasites.
  • Kills fleas and prevent infestation by targeting them before they lay eggs.
  • Kills 5 species of ticks, including Gulf Coast ticks, Deer ticks, American dog ticks, Lone Star ticks, and Brown dog sticks.
  • Treats gastrointestinal worms such as roundworms and hookworms.
  • Prevents heartworm disease.

Simparica Trio: An All-Round Treatment Suited for All Dogs

All dogs and puppies love the Simparica Trio chews. Its delicious liver flavor is irresistible to dogs, making it easy to administer without any hassle.

These chews are suitable for puppies and dogs older than 8 weeks and weighing over 2.8 lbs.

However, if your dog has a history of seizures, veterinary advice is needed before using Simparica Trio. This is because Simparica Trio contains Sarolaner, an isoxazoline derivative, which may trigger neurologic adverse reactions such as tremors, ataxia, and seizures.

Dosage and Administration Guide

Simparica Trio is available in different strengths based on the weight of your dog. The recommended dosage is one chew per month, given orally with or without food. It is important to ensure that your dog consumes the entire chew.

Many Problems, One Solution: Simparica Trio

Simparica Trio provides a convenient solution for dog owners who want to protect their pets against fleas, ticks, heartworms, and intestinal parasites all in one product. With its liver-flavored chewable, administering Simparica Trio is a breeze, ensuring that dogs receive the necessary protection without any hassle.

You can protect your lovely canine companion from the nuisance of harmful parasites by using an all-in-one Simparica Trio chewable. Buy the Simparica Trio Monthly Chewable from OurPetWarehouse and experience the best prices and convenient delivery options.

Don't wait until it's too late; buy Simparica Trio chewable today and keep your dog happy and healthy.

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Simparica Trio: A One-Chew Solution for Multiple Parasitic Problems

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