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Nexgard Plus or Nexgard Spectra – Which is Better for Your Canine?

  Jul 30, 2025

Nexgard Plus or Nexgard Spectra – Which is Better for Your Canine?

Nexgard Plus and Nexgard Spectra are two popular and effective parasitic treatments to keep your canine companion protected from a range of parasites. Over time, these treatments have become the preferred choice among pet parents due to their broad parasite coverage and ease of administration. But what exactly do they offer, and how do they differ from each other?

In this blog, we will highlight the benefits of these products so that you can make the best choice for your furry friend. Let's get started!

Nexgard Plus vs. Nexgard Spectra - An Overview

Nexgard Plus for Dogs:

Nexgard Plus for Dogs

Nexgard Plus is an oral, beef-flavored, multi-spectrum chewable treatment for dogs and puppies 8 weeks of age and older, weighing 4 lbs or greater. It is indicated for the prevention of heartworm disease and for the treatment and control of hookworm and roundworm infections.

This monthly treatment also kills adult fleas, treats and prevents flea infestations and treats and controls tick infestations caused by Black-legged tick, American dog tick, Brown dog tick, Lone star tick and longhorned tick. Moreover, it is indicated for the prevention of Lyme disease by killing Deer ticks.

Nexgard Spectra for Dogs:

Nexgard Spectra for Dogs

Nexgard Spectra is a broad-spectrum, beef-flavored, easy-to-administer, chewable treatment for dogs and puppies 8 weeks of age and older. It kills adult fleas, treats and prevents flea infestations and reduces the incidence of flea allergy dermatitis (FAD). It effectively treats and controls Brown dog tick and Asian longhorned tick infestations as well as roundworm, hookworm, whipworm, sarcoptic mange and ear mite infestations for a complete month. Moreover, it is helpful in the prevention of heartworm disease.

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What Makes Nexgard Plus and Nexgard Spectra Similar?

Mentioned below are some top reasons that make them great choices for your dog:

  1. Monthly formula: Nexgard Plus and Nexgard Spectra both offer monthly protection against multiple parasites.
  2. Convenient dosing: Both treatments are available in a soft, beef-flavored chew that is easily accepted by all dogs without any fuss.
  3. Broad-spectrum treatment: Nexgard Plus and Nexgard Spectra kill adult fleas, prevent flea infestations, and protect against Brown dog ticks, longhorned ticks, hookworms, and roundworms.
  4. Heartworm protection: Both treatments are effective in preventing heartworm disease in dogs.
  5. Suitability: Nexgard Plus and Nexgard Spectra are suitable for dogs and puppies from 8 weeks of age.
  6. Common ingredient: Formulated with a combination of powerful ingredients, both treatments contain one common ingredient, afoxolaner, that offers flea and tick protection.

How Is Nexgard Plus Different from Nexgard Spectra?

Let's have a quick look at the basic features that set these treatments apart from each other:

  1. Composition: The main difference between the two treatments is their composition. Nexgard Plus is a combination of three actives, afoxolaner, moxidectin, and pyrantel, whereas Nexgard Spectra contains afoxolaner and milbemycin oxime.
  2. Tick coverage: Nexgard Plus protects from Black-legged tick, American dog tick, Brown dog tick, Lone star tick and Asian longhorned tick infestations, whereas Nexgard Spectra protects against Brown dog ticks and Asian longhorned ticks.
  3. Other parasites: Nexgard Spectra offers protection from whipworm, sarcoptic mange, and ear mite infestations, whereas Nexgard Plus is not effective against these parasites.
  4. Lyme disease prevention: Nexgard Plus is indicated for the prevention of Lyme disease, whereas Nexgard Spectra has no such claims.

Nexgard Plus and Nexgard Spectra - Comparison Table

The chart below shows the comparison of the characteristics of Nexgard Plus and Nexgard Spectra:

Nexgard Plus vs Nexgard Spectra for Dogs - Comparison Chart

Key Takeaways

To conclude, it can be said that both Nexgard Plus and Nexgard Spectra are ideal treatments when it comes to keeping your canine companion protected from multiple parasites. Both treatments protect against fleas, ticks, roundworms, hookworms and effectively prevent heartworm disease in dogs and puppies from 8 weeks of age. However, if you are looking for additional protection from whipworms, sarcoptic mange and ear mites, go for Nexgard Spectra. For broader tick coverage and Lyme disease prevention, you should choose Nexgard Plus.

No matter which treatment you choose always consider your dog's preferences and requirements and consult your veterinarian for tailored recommendations.


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